Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3983057..3983524 Replicon chromosome
Accession NC_015566
Organism Serratia sp. AS12

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3Z4I7
Locus tag SERAS12_RS18655 Protein ID WP_013814082.1
Coordinates 3983057..3983326 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U3Z4H1
Locus tag SERAS12_RS18660 Protein ID WP_013814083.1
Coordinates 3983330..3983524 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS12_RS18625 3978121..3978636 + 516 WP_013814078.1 hypothetical protein -
SERAS12_RS18630 3978675..3978923 + 249 WP_006316897.1 GlsB/YeaQ/YmgE family stress response membrane protein -
SERAS12_RS18635 3978973..3980253 - 1281 WP_013814079.1 uracil permease -
SERAS12_RS18640 3980446..3981072 - 627 WP_006316899.1 uracil phosphoribosyltransferase -
SERAS12_RS18645 3981328..3982365 + 1038 WP_013814080.1 phosphoribosylformylglycinamidine cyclo-ligase -
SERAS12_RS18650 3982365..3983003 + 639 WP_013814081.1 phosphoribosylglycinamide formyltransferase -
SERAS12_RS18655 3983057..3983326 - 270 WP_013814082.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SERAS12_RS18660 3983330..3983524 - 195 WP_013814083.1 hypothetical protein Antitoxin
SERAS12_RS18665 3983671..3984222 + 552 WP_004951898.1 spermidine N1-acetyltransferase -
SERAS12_RS26310 3984269..3984412 - 144 Protein_3694 IS4 family transposase -
SERAS12_RS18670 3984621..3984986 - 366 WP_013814084.1 DUF596 domain-containing protein -
SERAS12_RS26520 3984995..3985758 - 764 Protein_3696 hypothetical protein -
SERAS12_RS18680 3986120..3986374 + 255 Protein_3697 spermidine acetyltransferase -
SERAS12_RS18685 3986491..3986826 - 336 WP_013814086.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10641.22 Da        Isoelectric Point: 6.0726

>T25263 WP_013814082.1 NC_015566:c3983326-3983057 [Serratia sp. AS12]
MRIEWSREAQEELWNIIDYIDDRNPQAALILQREIETAVHSLSLNPFMYRLGRVDNTREIVVHPNYLIVYRIIGHIEVLS
VIHAKREYP

Download         Length: 270 bp

>T25263 NC_015566:c3983326-3983057 [Serratia sp. AS12]
ATGCGGATAGAATGGAGTCGTGAAGCTCAGGAAGAGCTATGGAACATTATTGATTATATTGATGATAGAAACCCGCAGGC
GGCGCTCATTTTACAGCGCGAGATCGAAACGGCGGTGCATTCGCTGTCGCTGAATCCCTTTATGTACCGGTTGGGCAGAG
TAGATAACACTCGTGAGATTGTCGTCCATCCCAACTACCTGATTGTTTATAGAATCATCGGACATATAGAAGTTCTTAGT
GTTATTCACGCTAAACGAGAATATCCCTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7443.65 Da        Isoelectric Point: 10.2045

>AT25263 WP_013814083.1 NC_015566:c3983524-3983330 [Serratia sp. AS12]
MVIKTSLSTQPTAEVAEQGESYDRWFRAKIEAAINSEKPRIPHEQVMNEMQIRLAAKKKIRKME

Download         Length: 195 bp

>AT25263 NC_015566:c3983524-3983330 [Serratia sp. AS12]
ATGGTGATCAAAACCTCCCTCTCCACCCAGCCCACAGCTGAGGTAGCCGAACAAGGCGAAAGTTACGATCGTTGGTTCCG
GGCCAAGATTGAAGCAGCCATTAACAGCGAAAAACCAAGAATTCCGCACGAGCAGGTCATGAACGAGATGCAAATTCGTT
TAGCTGCAAAGAAAAAGATACGCAAAATGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Z4I7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3Z4H1

References