Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5000234..5001915 Replicon chromosome
Accession NZ_CP101764
Organism Klebsiella pneumoniae strain hvKP319

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NPJ83_RS24680 Protein ID WP_002885155.1
Coordinates 5000234..5001151 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NPJ83_RS24685 Protein ID WP_004151732.1
Coordinates 5001157..5001915 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ83_RS24660 (NPJ83_24660) 4995540..4997060 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NPJ83_RS24665 (NPJ83_24665) 4997057..4998055 + 999 WP_002885172.1 ribose ABC transporter permease -
NPJ83_RS24670 (NPJ83_24670) 4998086..4999027 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NPJ83_RS24675 (NPJ83_24675) 4999102..5000109 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NPJ83_RS24680 (NPJ83_24680) 5000234..5001151 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NPJ83_RS24685 (NPJ83_24685) 5001157..5001915 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NPJ83_RS24690 (NPJ83_24690) 5002001..5002729 - 729 WP_002885152.1 response regulator transcription factor -
NPJ83_RS24695 (NPJ83_24695) 5003002..5005149 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NPJ83_RS24700 (NPJ83_24700) 5005379..5006065 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T252622 WP_002885155.1 NZ_CP101764:c5001151-5000234 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT252622 WP_004151732.1 NZ_CP101764:c5001915-5001157 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References