Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3216405..3217030 Replicon chromosome
Accession NC_015566
Organism Serratia sp. AS12

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U3Z353
Locus tag SERAS12_RS15035 Protein ID WP_013813456.1
Coordinates 3216405..3216587 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7U4DXE6
Locus tag SERAS12_RS15040 Protein ID WP_013813457.1
Coordinates 3216617..3217030 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS12_RS15030 3212267..3216238 + 3972 WP_013813455.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
SERAS12_RS15035 3216405..3216587 + 183 WP_013813456.1 type II toxin-antitoxin system HicA family toxin Toxin
SERAS12_RS15040 3216617..3217030 + 414 WP_013813457.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SERAS12_RS15045 3217063..3217815 - 753 WP_013813458.1 L-cystine ABC transporter ATP-binding protein YecC -
SERAS12_RS15050 3217819..3218481 - 663 WP_013813459.1 cystine ABC transporter permease -
SERAS12_RS15055 3218481..3219281 - 801 WP_013813460.1 cystine ABC transporter substrate-binding protein -
SERAS12_RS15060 3219396..3220388 - 993 WP_013813461.1 D-cysteine desulfhydrase -
SERAS12_RS15065 3220514..3221023 - 510 WP_013813462.1 flagella biosynthesis regulatory protein FliZ -
SERAS12_RS15070 3221080..3221802 - 723 WP_013813463.1 RNA polymerase sigma factor FliA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6992.28 Da        Isoelectric Point: 11.3081

>T25262 WP_013813456.1 NC_015566:3216405-3216587 [Serratia sp. AS12]
VKSSELIRLLEREGWVLERIKGSHHQFKHPRSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Download         Length: 183 bp

>T25262 NC_015566:3216405-3216587 [Serratia sp. AS12]
GTGAAAAGTTCAGAACTGATCAGGCTGTTAGAACGAGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
TAAACACCCGAGATCTCGTTTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAGATCA
TGAAAGATGCCGGGCTGTGCTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15038.71 Da        Isoelectric Point: 4.6961

>AT25262 WP_013813457.1 NC_015566:3216617-3217030 [Serratia sp. AS12]
MFYPAYVHSDLDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELSKAG

Download         Length: 414 bp

>AT25262 NC_015566:3216617-3217030 [Serratia sp. AS12]
ATGTTCTACCCTGCTTATGTACATTCAGACCTCGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGTTGTTATTT
TGCCGGCGATACCCTCGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGACGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATCCCACGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACACCCTGAACGGCGGACAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGTATCAATATCACCCTGCCGCACCGCTTGTTGAACCG
CATCGATTCACTGGTGCAGCAGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGTAATGAATTAT
CGAAAGCCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Z353

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4DXE6

References