Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 6347788..6348362 Replicon chromosome
Accession NZ_CP101752
Organism Pseudomonas citronellolis strain C12

Toxin (Protein)


Gene name vapC Uniprot ID A0A4Z0IFX5
Locus tag NOX82_RS27895 Protein ID WP_058073004.1
Coordinates 6347788..6348153 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID W5ISP5
Locus tag NOX82_RS27900 Protein ID WP_009613188.1
Coordinates 6348147..6348362 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOX82_RS27875 (NOX82_27875) 6343332..6345743 + 2412 WP_074982899.1 TonB-dependent receptor -
NOX82_RS27880 (NOX82_27880) 6345751..6346899 + 1149 WP_116424334.1 PepSY domain-containing protein -
NOX82_RS27885 (NOX82_27885) 6346896..6347078 + 183 WP_116424333.1 hypothetical protein -
NOX82_RS27890 (NOX82_27890) 6347075..6347800 + 726 WP_256512967.1 hypothetical protein -
NOX82_RS27895 (NOX82_27895) 6347788..6348153 - 366 WP_058073004.1 type II toxin-antitoxin system VapC family toxin Toxin
NOX82_RS27900 (NOX82_27900) 6348147..6348362 - 216 WP_009613188.1 CopG family transcriptional regulator Antitoxin
NOX82_RS27905 (NOX82_27905) 6348431..6350455 - 2025 WP_256512970.1 oligopeptide transporter, OPT family -
NOX82_RS27910 (NOX82_27910) 6350706..6351542 - 837 WP_256512972.1 taurine dioxygenase -
NOX82_RS27915 (NOX82_27915) 6351771..6352589 - 819 WP_256512974.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13380.44 Da        Isoelectric Point: 5.8613

>T252608 WP_058073004.1 NZ_CP101752:c6348153-6347788 [Pseudomonas citronellolis]
MVKALFDTNILIDYLNGHEQARDELRRYDDPAISIVTWMEVMIGATPATAAATRAFLDSFALVPLDASVAERAVAVRQAL
RVKLPDAIIKASAEVQGRLLVTRNTRDFPVDDAGVRLPYRL

Download         Length: 366 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8033.94 Da        Isoelectric Point: 4.7616

>AT252608 WP_009613188.1 NZ_CP101752:c6348362-6348147 [Pseudomonas citronellolis]
MRTLVDIPAEHLEALNALGEQQQQSRAALIREAVAEYLVRHRRQDAEAAFGLWNGSAGDGLAYQEKVREEW

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z0IFX5

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5D6Z2

References