Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 6324451..6325118 Replicon chromosome
Accession NZ_CP101752
Organism Pseudomonas citronellolis strain C12

Toxin (Protein)


Gene name VapC1 Uniprot ID W5ISM6
Locus tag NOX82_RS27795 Protein ID WP_009613158.1
Coordinates 6324708..6325118 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag NOX82_RS27790 Protein ID WP_253412216.1
Coordinates 6324451..6324711 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOX82_RS27765 (NOX82_27765) 6319731..6319973 - 243 WP_074981193.1 YdcH family protein -
NOX82_RS27770 (NOX82_27770) 6320166..6320579 + 414 WP_249918704.1 large-conductance mechanosensitive channel protein MscL -
NOX82_RS27775 (NOX82_27775) 6320597..6322150 - 1554 WP_256512943.1 TerC family protein -
NOX82_RS27780 (NOX82_27780) 6322339..6323115 - 777 WP_253392706.1 ferredoxin--NADP reductase -
NOX82_RS27785 (NOX82_27785) 6323244..6324368 + 1125 WP_256515414.1 class I SAM-dependent methyltransferase -
NOX82_RS27790 (NOX82_27790) 6324451..6324711 + 261 WP_253412216.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NOX82_RS27795 (NOX82_27795) 6324708..6325118 + 411 WP_009613158.1 type II toxin-antitoxin system VapC family toxin Toxin
NOX82_RS27800 (NOX82_27800) 6325823..6326398 - 576 WP_256512950.1 nucleotidyltransferase family protein -
NOX82_RS27805 (NOX82_27805) 6326395..6327363 - 969 WP_074982920.1 XdhC family protein -
NOX82_RS27810 (NOX82_27810) 6327365..6328600 - 1236 WP_256512953.1 cytochrome c -
NOX82_RS27815 (NOX82_27815) 6328603..6329136 - 534 WP_009613171.1 (2Fe-2S)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(11-49)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15448.80 Da        Isoelectric Point: 7.1891

>T252607 WP_009613158.1 NZ_CP101752:6324708-6325118 [Pseudomonas citronellolis]
VKYLLDTNILIYLLKNRPESVARRVNALPADAGLCMSFFTYAELLKGAERSTRRSEVLRQLERLTRQVPVVYDGTPRLCE
HYATQFTRLKLAGTPIGANDLWIACHALALEATLVTHNTREFERIDGLCLEDWAAE

Download         Length: 411 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9745.90 Da        Isoelectric Point: 4.2932

>AT252607 WP_253412216.1 NZ_CP101752:6324451-6324711 [Pseudomonas citronellolis]
MSSPTLPSRVFMNGNSQAVRIPQEFRLDASRVEIRRQANGDLVIHPLPEDRGEALLQALSGFDEAFIEALEEGQREQPPM
QEREEL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z0IIB3

Antitoxin

Source ID Structure

References