Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 5933813..5934390 Replicon chromosome
Accession NZ_CP101752
Organism Pseudomonas citronellolis strain C12

Toxin (Protein)


Gene name hicA Uniprot ID A0A4Z0IIZ1
Locus tag NOX82_RS25955 Protein ID WP_074984997.1
Coordinates 5933813..5934067 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4Z0ILE6
Locus tag NOX82_RS25960 Protein ID WP_074984995.1
Coordinates 5934064..5934390 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOX82_RS25930 (NOX82_25930) 5929260..5929913 + 654 WP_116425555.1 TetR family transcriptional regulator -
NOX82_RS25935 (NOX82_25935) 5929892..5930089 - 198 WP_009616013.1 cation transporter -
NOX82_RS25940 (NOX82_25940) 5930242..5930646 + 405 WP_058070664.1 hypothetical protein -
NOX82_RS25945 (NOX82_25945) 5930754..5933177 + 2424 WP_256512658.1 heavy metal translocating P-type ATPase -
NOX82_RS25950 (NOX82_25950) 5933164..5933565 + 402 WP_253392247.1 Cu(I)-responsive transcriptional regulator -
NOX82_RS25955 (NOX82_25955) 5933813..5934067 + 255 WP_074984997.1 type II toxin-antitoxin system HicA family toxin Toxin
NOX82_RS25960 (NOX82_25960) 5934064..5934390 + 327 WP_074984995.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NOX82_RS25965 (NOX82_25965) 5934818..5935708 - 891 WP_256512659.1 EamA family transporter -
NOX82_RS25970 (NOX82_25970) 5935798..5936349 - 552 WP_256515406.1 nucleotidyltransferase family protein -
NOX82_RS25975 (NOX82_25975) 5936346..5937239 - 894 WP_256512660.1 PA4780 family RIO1-like protein kinase -
NOX82_RS25980 (NOX82_25980) 5937332..5938513 - 1182 WP_256512661.1 two-component system response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-73)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9419.81 Da        Isoelectric Point: 10.1609

>T252606 WP_074984997.1 NZ_CP101752:5933813-5934067 [Pseudomonas citronellolis]
MNSRQRATLEALYAVPTPCNLEWARIESLLLSLGARLIEGNGSRVRFELNGVIASFHRPHPAKEAKPYQVRDARAFIERA
GYAP

Download         Length: 255 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12075.71 Da        Isoelectric Point: 6.0781

>AT252606 WP_074984995.1 NZ_CP101752:5934064-5934390 [Pseudomonas citronellolis]
MSPMKYKGYVARIEYSDDDGLFIGHIAGIQDVIGFHGESVSELRQLFHEAVDDYLDTCAKLGREPQKPYSGKLSLRLDPA
LHARVALKAELSNKSINQWVAERLSEAV

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z0IIZ1

Antitoxin

Source ID Structure
AlphaFold DB A0A4Z0ILE6

References