Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 684002..684635 Replicon chromosome
Accession NZ_CP101752
Organism Pseudomonas citronellolis strain C12

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NOX82_RS03040 Protein ID WP_058073290.1
Coordinates 684002..684184 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4Z0ILP9
Locus tag NOX82_RS03045 Protein ID WP_058073289.1
Coordinates 684213..684635 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOX82_RS03020 (NOX82_03020) 681620..681778 + 159 WP_009615518.1 YqaE/Pmp3 family membrane protein -
NOX82_RS03025 (NOX82_03025) 682095..682583 - 489 WP_058073292.1 Bro-N domain-containing protein -
NOX82_RS03030 (NOX82_03030) 683042..683224 + 183 WP_009615522.1 type II toxin-antitoxin system HicA family toxin -
NOX82_RS03035 (NOX82_03035) 683257..683661 + 405 WP_009615524.1 type II toxin-antitoxin system HicB family antitoxin -
NOX82_RS03040 (NOX82_03040) 684002..684184 + 183 WP_058073290.1 type II toxin-antitoxin system HicA family toxin Toxin
NOX82_RS03045 (NOX82_03045) 684213..684635 + 423 WP_058073289.1 helix-turn-helix domain-containing protein Antitoxin
NOX82_RS03050 (NOX82_03050) 684660..685430 - 771 WP_249917986.1 NERD domain-containing protein -
NOX82_RS03060 (NOX82_03060) 685701..689435 - 3735 WP_256514060.1 bifunctional diguanylate cyclase/phosphodiesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6975.02 Da        Isoelectric Point: 10.2145

>T252595 WP_058073290.1 NZ_CP101752:684002-684184 [Pseudomonas citronellolis]
MKYSEFRRWLKSQGVQFEPGKGSHFKVYFGDNQTIFPDHGAKEMGEGLRKKIIKDLGLKD

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15056.35 Da        Isoelectric Point: 4.9092

>AT252595 WP_058073289.1 NZ_CP101752:684213-684635 [Pseudomonas citronellolis]
MFDYPVTVHHEAGSVWVSCDDVPELASAGDTEEEALLDAIDGLETALSMYVERKVPIPLPSRAAPGQPVVCLPALTAAKA
ALWNAMQAQGVNKAEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALAVLGQRIALTVIAA

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4Z0ILP9

References