Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 5648022..5648547 Replicon chromosome
Accession NZ_CP101750
Organism Streptomyces sp. Je 1-369

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NOO62_RS25885 Protein ID WP_268773250.1
Coordinates 5648022..5648285 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NOO62_RS25890 Protein ID WP_268773251.1
Coordinates 5648278..5648547 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOO62_RS25865 (NOO62_25885) 5644086..5645078 + 993 WP_268773246.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
NOO62_RS25870 (NOO62_25890) 5645130..5645870 + 741 WP_268773247.1 ROK family protein -
NOO62_RS25875 (NOO62_25895) 5645887..5646396 - 510 WP_268773248.1 hypothetical protein -
NOO62_RS25880 (NOO62_25900) 5646798..5647886 + 1089 WP_268773249.1 redox-regulated ATPase YchF -
NOO62_RS25885 (NOO62_25905) 5648022..5648285 - 264 WP_268773250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOO62_RS25890 (NOO62_25910) 5648278..5648547 - 270 WP_268773251.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NOO62_RS25895 (NOO62_25915) 5648663..5648830 + 168 WP_268775984.1 hypothetical protein -
NOO62_RS25900 (NOO62_25920) 5648836..5648919 + 84 Protein_5106 type II toxin-antitoxin system YoeB family toxin -
NOO62_RS25905 (NOO62_25925) 5648973..5650442 + 1470 WP_268773252.1 amidase -
NOO62_RS25910 (NOO62_25930) 5650400..5651362 - 963 WP_268773253.1 CU044_5270 family protein -
NOO62_RS25915 (NOO62_25935) 5651359..5651973 - 615 WP_268773254.1 RNA polymerase sigma factor -
NOO62_RS25920 (NOO62_25940) 5652023..5653168 - 1146 WP_268773255.1 threonine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-59)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10034.43 Da        Isoelectric Point: 7.0123

>T252592 WP_268773250.1 NZ_CP101750:c5648285-5648022 [Streptomyces sp. Je 1-369]
VSEYRTVFRPEAQDELRKIPRAMALRILAKLTELESDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHVGD
RSTAYET

Download         Length: 264 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10284.69 Da        Isoelectric Point: 4.5235

>AT252592 WP_268773251.1 NZ_CP101750:c5648547-5648278 [Streptomyces sp. Je 1-369]
MTQSMPVESIRDVRAHLAEVVERADREDVPTVITRRGKEVAAVVSIDVLRKYQEWEEREINRIIDERMADPAPGIPIEDI
MRETLARSE

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References