Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5558290..5559980 Replicon chromosome
Accession NZ_CP101743
Organism Comamonas sp. C11

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NOX35_RS25675 Protein ID WP_256495181.1
Coordinates 5559102..5559980 (-) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NOX35_RS25670 Protein ID WP_256495180.1
Coordinates 5558290..5559096 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOX35_RS25650 (NOX35_25650) 5554285..5555061 - 777 WP_256495176.1 SDR family oxidoreductase -
NOX35_RS25655 (NOX35_25655) 5555378..5556136 - 759 WP_182284977.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
NOX35_RS25660 (NOX35_25660) 5556268..5557254 - 987 WP_256495179.1 tripartite tricarboxylate transporter substrate binding protein -
NOX35_RS25665 (NOX35_25665) 5557447..5558247 - 801 WP_003072481.1 aspartate dehydrogenase -
NOX35_RS25670 (NOX35_25670) 5558290..5559096 - 807 WP_256495180.1 IclR family transcriptional regulator Antitoxin
NOX35_RS25675 (NOX35_25675) 5559102..5559980 - 879 WP_256495181.1 alpha/beta hydrolase Toxin
NOX35_RS25680 (NOX35_25680) 5559989..5560522 - 534 WP_003072476.1 cupin domain-containing protein -
NOX35_RS25685 (NOX35_25685) 5560782..5562458 - 1677 WP_256495184.1 long-chain-fatty-acid--CoA ligase -
NOX35_RS25690 (NOX35_25690) 5562672..5563736 - 1065 WP_182284983.1 fructose-bisphosphate aldolase class II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(44-277)

Antitoxin

Transcription regulator IclR, N-terminal

(19-69)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 30700.27 Da        Isoelectric Point: 6.2916

>T252589 WP_256495181.1 NZ_CP101743:c5559980-5559102 [Comamonas sp. C11]
MHEDLLSLKLQLLQTGFPERLVKLPQGVQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLVQSAPADADYAHALAQSLLVLGVRRCILVGHSLGALMAARLALMAAPGLVEQLVLISPAGGYGATAKAEQQAKVRE
GRLASLAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQAQGRLGMPVEVWVGEHDVV
TTPAACKSWSELLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS

Download         Length: 879 bp

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29258.23 Da        Isoelectric Point: 4.8919

>AT252589 WP_256495180.1 NZ_CP101743:c5559096-5558290 [Comamonas sp. C11]
MSETPEISTNEQDRYTVPALDRGLRLLACFGPEQPVWSAPELARSLELPRSTVFRMLTTLESSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
VQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGQVVAGLGMAIPFTELGPEK
TQLWVQKVLEAAETLSAHLRQQHPDHLR

Download         Length: 807 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References