Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2874712..2875313 Replicon chromosome
Accession NZ_CP101743
Organism Comamonas sp. C11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NOX35_RS13145 Protein ID WP_019042333.1
Coordinates 2874712..2875098 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A076PMR1
Locus tag NOX35_RS13150 Protein ID WP_034356765.1
Coordinates 2875098..2875313 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOX35_RS13130 (NOX35_13130) 2872179..2873489 - 1311 WP_256496868.1 DNA polymerase Y family protein -
NOX35_RS13135 (NOX35_13135) 2873434..2874234 - 801 WP_256496869.1 translesion DNA synthesis-associated protein ImuA -
NOX35_RS13140 (NOX35_13140) 2874414..2874623 - 210 WP_034356767.1 hypothetical protein -
NOX35_RS13145 (NOX35_13145) 2874712..2875098 - 387 WP_019042333.1 twitching motility protein PilT Toxin
NOX35_RS13150 (NOX35_13150) 2875098..2875313 - 216 WP_034356765.1 DUF2191 domain-containing protein Antitoxin
NOX35_RS13155 (NOX35_13155) 2875398..2876215 + 818 Protein_2543 SprT-like domain-containing protein -
NOX35_RS13160 (NOX35_13160) 2876369..2876695 + 327 WP_019042331.1 transposase -
NOX35_RS13165 (NOX35_13165) 2877032..2878705 - 1674 WP_230629841.1 phosphoethanolamine transferase -
NOX35_RS13170 (NOX35_13170) 2878957..2879346 + 390 WP_080571250.1 CzcE family metal-binding protein -
NOX35_RS13175 (NOX35_13175) 2879426..2879872 - 447 WP_019042328.1 Cd(II)/Pb(II)-responsive transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2610723..2909723 299000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13999.29 Da        Isoelectric Point: 5.0594

>T252588 WP_019042333.1 NZ_CP101743:c2875098-2874712 [Comamonas sp. C11]
MPVSVLVDTSVWVRHFREADTHLQELLMQDSVLMHSMVHAELACGTPPAPRADTLAALAMLRPSQEASIPETLEFLEQNK
LFGKGCGLVDLSLLASTLITPGALLWTADRRLADMATQLNVAYLPPLH

Download         Length: 387 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7519.50 Da        Isoelectric Point: 5.0166

>AT252588 WP_034356765.1 NZ_CP101743:c2875313-2875098 [Comamonas sp. C11]
MRSTFTIDDDVVNRARAVAAPGIAVPELVRLALETFTRVEAGKRLAALGGAAPNMPDVPRRGSEADAEDSR

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076PMR1

References