Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2833553..2834073 Replicon chromosome
Accession NZ_CP101740
Organism Sphingomonas qomolangmaensis strain S5-59

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NMP03_RS13550 Protein ID WP_256505985.1
Coordinates 2833750..2834073 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NMP03_RS13545 Protein ID WP_256505984.1
Coordinates 2833553..2833753 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMP03_RS13535 (NMP03_13535) 2829375..2830859 - 1485 WP_256505982.1 HWE histidine kinase domain-containing protein -
NMP03_RS13540 (NMP03_13540) 2830940..2833141 - 2202 WP_256505983.1 excinuclease ABC subunit UvrB -
NMP03_RS13545 (NMP03_13545) 2833553..2833753 + 201 WP_256505984.1 antitoxin MazE family protein Antitoxin
NMP03_RS13550 (NMP03_13550) 2833750..2834073 + 324 WP_256505985.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NMP03_RS13555 (NMP03_13555) 2834319..2835644 + 1326 WP_256505986.1 amidohydrolase -
NMP03_RS13560 (NMP03_13560) 2835803..2836990 - 1188 WP_256505987.1 MBL fold metallo-hydrolase -
NMP03_RS13565 (NMP03_13565) 2837168..2838691 - 1524 WP_256505988.1 fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(1-61)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11329.38 Da        Isoelectric Point: 11.0199

>T252587 WP_256505985.1 NZ_CP101740:2833750-2834073 [Sphingomonas qomolangmaensis]
MKRGDLVTIALPGDFGKPRPALIIQSDQFDQTGTVTVLLVSGTLVDAPLIRTTIDPTPGNGLRKRSQVMVDKAMSVKRGK
IGAPIGRLDAEAMLAVTRALAVFFAIA

Download         Length: 324 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7266.14 Da        Isoelectric Point: 4.5086

>AT252587 WP_256505984.1 NZ_CP101740:2833553-2833753 [Sphingomonas qomolangmaensis]
VQKRRDALRAAGLRPIQIWVPDTRRPGFAEECQRQARVVAAADAADHDLDAFIDAALVDLDPEGEV

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References