252581

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1363..1837 Replicon plasmid p2_150040X1B1
Accession NZ_CP101730
Organism Klebsiella pneumoniae strain 150040X1B1

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag NPN21_RS28860 Protein ID WP_004197762.1
Coordinates 1363..1629 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag NPN21_RS28865 Protein ID WP_000879771.1
Coordinates 1613..1837 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPN21_RS28850 (NPN21_28850) 332..877 + 546 WP_023317533.1 hypothetical protein -
NPN21_RS28855 (NPN21_28855) 943..1293 + 351 WP_004197756.1 hypothetical protein -
NPN21_RS28860 (NPN21_28860) 1363..1629 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPN21_RS28865 (NPN21_28865) 1613..1837 - 225 WP_000879771.1 DUF6290 family protein Antitoxin
NPN21_RS28870 (NPN21_28870) 2504..2716 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
NPN21_RS28875 (NPN21_28875) 2723..3232 - 510 WP_032433972.1 MbeB family mobilization protein -
NPN21_RS28880 (NPN21_28880) 3267..3701 - 435 Protein_7 relaxase/mobilization nuclease domain-containing protein -
NPN21_RS28885 (NPN21_28885) 3910..4254 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
NPN21_RS28890 (NPN21_28890) 4244..4420 - 177 WP_004197757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T252581 WP_004197762.1 NZ_CP101730:c1629-1363 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT252581 WP_000879771.1 NZ_CP101730:c1837-1613 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References