Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 95171..95796 Replicon plasmid pVir_150040X1B1
Accession NZ_CP101728
Organism Klebsiella pneumoniae strain 150040X1B1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NPN21_RS28340 Protein ID WP_000911313.1
Coordinates 95398..95796 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag NPN21_RS28335 Protein ID WP_000450520.1
Coordinates 95171..95398 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPN21_RS28335 (95171) 95171..95398 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
NPN21_RS28340 (95398) 95398..95796 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
NPN21_RS28345 (95805) 95805..97958 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
NPN21_RS28350 (98211) 98211..98942 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
NPN21_RS28355 (98974) 98974..99471 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / sitABCD iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA 1..172348 172348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T252574 WP_000911313.1 NZ_CP101728:95398-95796 [Klebsiella pneumoniae]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT252574 WP_000450520.1 NZ_CP101728:95171-95398 [Klebsiella pneumoniae]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References