Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5057643..5059324 Replicon chromosome
Accession NZ_CP101726
Organism Klebsiella pneumoniae strain 150040X1B1

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NPN21_RS25030 Protein ID WP_002885155.1
Coordinates 5057643..5058560 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NPN21_RS25035 Protein ID WP_004151732.1
Coordinates 5058566..5059324 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPN21_RS25010 (NPN21_25010) 5052949..5054469 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NPN21_RS25015 (NPN21_25015) 5054466..5055464 + 999 WP_002885172.1 ribose ABC transporter permease -
NPN21_RS25020 (NPN21_25020) 5055495..5056436 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NPN21_RS25025 (NPN21_25025) 5056511..5057518 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NPN21_RS25030 (NPN21_25030) 5057643..5058560 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NPN21_RS25035 (NPN21_25035) 5058566..5059324 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NPN21_RS25040 (NPN21_25040) 5059410..5060138 - 729 WP_002885152.1 response regulator transcription factor -
NPN21_RS25045 (NPN21_25045) 5060411..5062558 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NPN21_RS25050 (NPN21_25050) 5062788..5063474 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T252564 WP_002885155.1 NZ_CP101726:c5058560-5057643 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT252564 WP_004151732.1 NZ_CP101726:c5059324-5058566 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References