Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4901459..4901975 Replicon chromosome
Accession NZ_CP101726
Organism Klebsiella pneumoniae strain 150040X1B1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NPN21_RS24230 Protein ID WP_002886902.1
Coordinates 4901459..4901743 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NPN21_RS24235 Protein ID WP_002886901.1
Coordinates 4901733..4901975 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPN21_RS24205 (NPN21_24205) 4896943..4897206 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NPN21_RS24210 (NPN21_24210) 4897336..4897509 + 174 WP_002886906.1 hypothetical protein -
NPN21_RS24215 (NPN21_24215) 4897512..4898255 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NPN21_RS24220 (NPN21_24220) 4898612..4900750 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NPN21_RS24225 (NPN21_24225) 4900991..4901455 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NPN21_RS24230 (NPN21_24230) 4901459..4901743 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPN21_RS24235 (NPN21_24235) 4901733..4901975 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NPN21_RS24240 (NPN21_24240) 4902053..4903963 - 1911 WP_004152270.1 PRD domain-containing protein -
NPN21_RS24245 (NPN21_24245) 4903986..4905140 - 1155 WP_002886900.1 lactonase family protein -
NPN21_RS24250 (NPN21_24250) 4905206..4905946 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T252563 WP_002886902.1 NZ_CP101726:c4901743-4901459 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT252563 WP_002886901.1 NZ_CP101726:c4901975-4901733 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References