Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4798878..4799688 Replicon chromosome
Accession NZ_CP101726
Organism Klebsiella pneumoniae strain 150040X1B1

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NPN21_RS23745 Protein ID WP_002887280.1
Coordinates 4798878..4799411 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NPN21_RS23750 Protein ID WP_002887278.1
Coordinates 4799422..4799688 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPN21_RS23740 (NPN21_23740) 4797709..4798830 + 1122 WP_002887282.1 cupin domain-containing protein -
NPN21_RS23745 (NPN21_23745) 4798878..4799411 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NPN21_RS23750 (NPN21_23750) 4799422..4799688 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NPN21_RS23755 (NPN21_23755) 4799791..4801224 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
NPN21_RS23760 (NPN21_23760) 4801214..4801897 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NPN21_RS23765 (NPN21_23765) 4802069..4803454 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
NPN21_RS23770 (NPN21_23770) 4803472..4803816 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T252562 WP_002887280.1 NZ_CP101726:c4799411-4798878 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT252562 WP_002887278.1 NZ_CP101726:c4799688-4799422 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References