252550

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1421133..1422049 Replicon chromosome
Accession NZ_CP101718
Organism Bacillus halotolerans strain S-5

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag NPA28_RS07255 Protein ID WP_044156223.1
Coordinates 1421303..1422049 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag NPA28_RS07250 Protein ID WP_024121090.1
Coordinates 1421133..1421303 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPA28_RS07215 (NPA28_07215) 1417997..1418326 + 330 WP_044156231.1 XkdW family protein -
NPA28_RS07220 (NPA28_07220) 1418323..1418487 + 165 WP_044156230.1 XkdX family protein -
NPA28_RS07225 (NPA28_07225) 1418531..1419370 + 840 WP_044156229.1 hypothetical protein -
NPA28_RS07230 (NPA28_07230) 1419426..1419695 + 270 WP_044156228.1 hemolysin XhlA family protein -
NPA28_RS07235 (NPA28_07235) 1419707..1419970 + 264 WP_044156226.1 phage holin -
NPA28_RS07240 (NPA28_07240) 1419983..1420876 + 894 WP_217827104.1 N-acetylmuramoyl-L-alanine amidase -
NPA28_RS07245 (NPA28_07245) 1420912..1421049 - 138 WP_125825426.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NPA28_RS07250 (NPA28_07250) 1421133..1421303 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NPA28_RS07255 (NPA28_07255) 1421303..1422049 - 747 WP_044156223.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NPA28_RS07260 (NPA28_07260) 1422158..1423159 - 1002 WP_044156221.1 inorganic phosphate transporter -
NPA28_RS07265 (NPA28_07265) 1423172..1423789 - 618 WP_044156219.1 DUF47 domain-containing protein -
NPA28_RS07270 (NPA28_07270) 1424068..1425384 - 1317 WP_044156218.1 serine/threonine exchanger -
NPA28_RS07275 (NPA28_07275) 1425779..1426729 + 951 WP_059292934.1 ring-cleaving dioxygenase -
NPA28_RS07280 (NPA28_07280) 1426895..1426975 + 81 Protein_1371 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29102.52 Da        Isoelectric Point: 4.4373

>T252550 WP_044156223.1 NZ_CP101718:c1422049-1421303 [Bacillus halotolerans]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CYYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT252550 WP_024121090.1 NZ_CP101718:c1421303-1421133 [Bacillus halotolerans]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References