Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4462686..4463730 Replicon chromosome
Accession NZ_CP101705
Organism Escherichia coli strain 035152

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag NPL72_RS21785 Protein ID WP_000019186.1
Coordinates 4462686..4463234 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag NPL72_RS21790 Protein ID WP_000287252.1
Coordinates 4463257..4463730 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPL72_RS21750 (4457898) 4457898..4458449 - 552 WP_000515860.1 protein YmfL -
NPL72_RS21755 (4458493) 4458493..4458693 - 201 WP_000649477.1 YdaS family helix-turn-helix protein -
NPL72_RS21760 (4458784) 4458784..4459458 + 675 WP_000859462.1 LexA family transcriptional repressor -
NPL72_RS21765 (4460125) 4460125..4460487 + 363 WP_000135682.1 protein YfdP -
NPL72_RS21770 (4460553) 4460553..4461377 + 825 WP_001753751.1 DUF2303 family protein -
NPL72_RS21775 (4461564) 4461564..4462346 + 783 WP_000610754.1 hypothetical protein -
NPL72_RS21780 (4462383) 4462383..4462652 + 270 WP_001093912.1 pyocin activator PrtN family protein -
NPL72_RS21785 (4462686) 4462686..4463234 - 549 WP_000019186.1 hypothetical protein Toxin
NPL72_RS21790 (4463257) 4463257..4463730 - 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
NPL72_RS21795 (4464035) 4464035..4464139 - 105 Protein_4264 tRNA-dihydrouridine synthase -
NPL72_RS21800 (4464502) 4464502..4465518 - 1017 WP_000912595.1 DUF2713 family protein -
NPL72_RS21805 (4465836) 4465836..4466351 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
NPL72_RS21810 (4466393) 4466393..4466602 - 210 WP_001030593.1 CsbD family protein -
NPL72_RS21815 (4466718) 4466718..4468043 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
NPL72_RS21820 (4468116) 4468116..4468724 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4437643..4468724 31081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T252542 WP_000019186.1 NZ_CP101705:c4463234-4462686 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT252542 WP_000287252.1 NZ_CP101705:c4463730-4463257 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References