Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3568271..3568889 Replicon chromosome
Accession NZ_CP101705
Organism Escherichia coli strain 035152

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NPL72_RS17355 Protein ID WP_001291435.1
Coordinates 3568671..3568889 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NPL72_RS17350 Protein ID WP_000344800.1
Coordinates 3568271..3568645 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPL72_RS17340 (3563360) 3563360..3564553 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NPL72_RS17345 (3564576) 3564576..3567725 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NPL72_RS17350 (3568271) 3568271..3568645 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NPL72_RS17355 (3568671) 3568671..3568889 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NPL72_RS17360 (3569061) 3569061..3569612 + 552 WP_000102568.1 maltose O-acetyltransferase -
NPL72_RS17365 (3569728) 3569728..3570198 + 471 WP_000136192.1 YlaC family protein -
NPL72_RS17370 (3570362) 3570362..3571912 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NPL72_RS17375 (3571954) 3571954..3572307 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NPL72_RS17385 (3572686) 3572686..3572997 + 312 WP_000409911.1 MGMT family protein -
NPL72_RS17390 (3573028) 3573028..3573600 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T252540 WP_001291435.1 NZ_CP101705:3568671-3568889 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT252540 WP_000344800.1 NZ_CP101705:3568271-3568645 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References