Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2468763..2470351 Replicon chromosome
Accession NZ_CP101705
Organism Escherichia coli strain 035152

Toxin (Protein)


Gene name hipA Uniprot ID F4NFZ0
Locus tag NPL72_RS11990 Protein ID WP_001125463.1
Coordinates 2469029..2470351 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NPL72_RS11985 Protein ID WP_001296726.1
Coordinates 2468763..2469029 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPL72_RS11980 (2463848) 2463848..2468554 + 4707 Protein_2343 ECSE_1600 family autotransporter -
NPL72_RS11985 (2468763) 2468763..2469029 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NPL72_RS11990 (2469029) 2469029..2470351 + 1323 WP_001125463.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NPL72_RS11995 (2470663) 2470663..2470871 + 209 Protein_2346 AraC family transcriptional regulator -
NPL72_RS12000 (2471303) 2471303..2471866 + 564 WP_001373493.1 type 1 fimbrial major subunit FimA -
NPL72_RS12005 (2472227) 2472227..2472364 + 138 Protein_2348 hypothetical protein -
NPL72_RS12010 (2472418) 2472418..2473115 + 698 WP_151884388.1 IS1 family transposase -
NPL72_RS12015 (2473127) 2473127..2473714 + 588 Protein_2350 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA / focC 2463094..2486964 23870


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49422.05 Da        Isoelectric Point: 9.1203

>T252539 WP_001125463.1 NZ_CP101705:2469029-2470351 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT252539 WP_001296726.1 NZ_CP101705:2468763-2469029 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9IYX0

Antitoxin

Source ID Structure

References