Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1637197..1637753 Replicon chromosome
Accession NC_015566
Organism Serratia sp. AS12

Toxin (Protein)


Gene name ccdB Uniprot ID A0A7U4DW07
Locus tag SERAS12_RS07710 Protein ID WP_013812173.1
Coordinates 1637436..1637753 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A7U3Z0I2
Locus tag SERAS12_RS07705 Protein ID WP_013812172.1
Coordinates 1637197..1637433 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS12_RS07690 1633623..1635161 + 1539 WP_013812169.1 glutathione ABC transporter substrate-binding protein GsiB -
SERAS12_RS07695 1635214..1636134 + 921 WP_013812170.1 glutathione ABC transporter permease GsiC -
SERAS12_RS07700 1636144..1637052 + 909 WP_013812171.1 glutathione ABC transporter permease GsiD -
SERAS12_RS07705 1637197..1637433 + 237 WP_013812172.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SERAS12_RS07710 1637436..1637753 + 318 WP_013812173.1 CcdB family protein Toxin
SERAS12_RS07715 1637787..1638629 - 843 WP_004942338.1 S-formylglutathione hydrolase -
SERAS12_RS07720 1638644..1639771 - 1128 WP_004942340.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
SERAS12_RS07725 1639800..1640717 - 918 WP_013812174.1 LysR family transcriptional regulator -
SERAS12_RS07730 1640825..1641982 + 1158 WP_013812175.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11972.92 Da        Isoelectric Point: 5.8267

>T25253 WP_013812173.1 NC_015566:1637436-1637753 [Serratia sp. AS12]
MQFTVYANTGKSAVYPLLLDVTNDIIEQLNRRVMIPLLPIEKYPASTRPERLNPLVRLVDDNEYAVMTHEMASIPVRILG
AEFCDASQYRTKVKAAIDFLFDGIR

Download         Length: 318 bp

>T25253 NC_015566:1637436-1637753 [Serratia sp. AS12]
ATGCAATTTACGGTATACGCGAATACGGGGAAAAGCGCAGTCTATCCTCTGCTGCTTGATGTGACGAACGATATCATCGA
GCAATTAAATCGCCGAGTTATGATCCCGTTATTACCCATTGAAAAGTATCCGGCCAGTACTCGCCCGGAACGCTTGAACC
CTTTGGTCAGGCTGGTGGATGACAACGAGTACGCCGTTATGACTCATGAGATGGCAAGTATTCCCGTTCGTATCCTGGGC
GCTGAATTTTGCGATGCTTCCCAATACCGAACCAAGGTGAAAGCCGCAATAGATTTTCTTTTCGACGGTATCAGATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9184.30 Da        Isoelectric Point: 6.7189

>AT25253 WP_013812172.1 NC_015566:1637197-1637433 [Serratia sp. AS12]
MPVKQRTTQSVTMAMERSLLSRAREAGINLSTTLNTALDAELRQHEMRKWKEENREAIDALNRFHEEHGCFSDEYRTF

Download         Length: 237 bp

>AT25253 NC_015566:1637197-1637433 [Serratia sp. AS12]
ATGCCAGTAAAACAACGAACGACCCAAAGCGTTACCATGGCGATGGAACGCAGTTTACTGAGCCGTGCACGTGAGGCGGG
CATTAACCTCAGTACTACGCTGAATACTGCTTTGGATGCCGAATTGCGTCAGCATGAGATGAGGAAATGGAAGGAAGAAA
ACCGAGAAGCGATCGATGCTTTAAATCGTTTTCATGAAGAACATGGCTGTTTCAGTGACGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4DW07

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3Z0I2

References