Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 979041..979695 Replicon chromosome
Accession NZ_CP101705
Organism Escherichia coli strain 035152

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NPL72_RS04845 Protein ID WP_000244777.1
Coordinates 979288..979695 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NPL72_RS04840 Protein ID WP_000354046.1
Coordinates 979041..979307 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPL72_RS04815 (974329) 974329..975072 + 744 Protein_946 SDR family oxidoreductase -
NPL72_RS04820 (975129) 975129..976562 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
NPL72_RS04825 (976607) 976607..976918 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
NPL72_RS04830 (977082) 977082..977741 + 660 WP_000250274.1 hemolysin III family protein -
NPL72_RS04835 (977818) 977818..978798 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NPL72_RS04840 (979041) 979041..979307 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NPL72_RS04845 (979288) 979288..979695 + 408 WP_000244777.1 protein YgfX Toxin
NPL72_RS04850 (979735) 979735..980256 - 522 WP_001055874.1 flavodoxin FldB -
NPL72_RS04855 (980368) 980368..981264 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NPL72_RS04860 (981289) 981289..981999 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NPL72_RS04865 (982005) 982005..983738 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T252529 WP_000244777.1 NZ_CP101705:979288-979695 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT252529 WP_000354046.1 NZ_CP101705:979041-979307 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References