Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1151780..1152402 Replicon chromosome
Accession NC_015566
Organism Serratia sp. AS12

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag SERAS12_RS05340 Protein ID WP_006322256.1
Coordinates 1151780..1151983 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag SERAS12_RS05345 Protein ID WP_004949348.1
Coordinates 1152034..1152402 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS12_RS25330 1148146..1148820 - 675 WP_013811773.1 helix-turn-helix domain-containing protein -
SERAS12_RS05335 1149060..1151069 - 2010 WP_013811774.1 right-handed parallel beta-helix repeat-containing protein -
SERAS12_RS05340 1151780..1151983 - 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
SERAS12_RS05345 1152034..1152402 - 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
SERAS12_RS05350 1152562..1152915 - 354 WP_071880436.1 hypothetical protein -
SERAS12_RS26400 1153222..1153371 + 150 WP_168157926.1 hypothetical protein -
SERAS12_RS05360 1153368..1154081 + 714 WP_013811776.1 ABC transporter ATP-binding protein -
SERAS12_RS05365 1154078..1154935 + 858 WP_013811777.1 metal ABC transporter permease -
SERAS12_RS05370 1154961..1155839 + 879 WP_013811778.1 metal ABC transporter substrate-binding protein -
SERAS12_RS05375 1155955..1156095 - 141 WP_013811779.1 type B 50S ribosomal protein L36 -
SERAS12_RS05380 1156108..1156362 - 255 WP_004949355.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T25252 WP_006322256.1 NC_015566:c1151983-1151780 [Serratia sp. AS12]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T25252 NC_015566:c1151983-1151780 [Serratia sp. AS12]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAACTAGAGCTGTTCTACTCTGCTGCCGACCACCGTTTGGCCGAGCTCACCATGAATAAGC
TGTACGATAAGATCCCTGTTGCCGTTTGGAAATTCGTACGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT25252 WP_004949348.1 NC_015566:c1152402-1152034 [Serratia sp. AS12]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT25252 NC_015566:c1152402-1152034 [Serratia sp. AS12]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
CACGCTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTATGGTATTAATGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References