Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 63068..63984 Replicon plasmid pMD9A
Accession NZ_CP101701
Organism Pseudomonas asiatica strain MD9

Toxin (Protein)


Gene name slvT Uniprot ID A0A212BIN6
Locus tag NOV18_RS27900 Protein ID WP_021018402.1
Coordinates 63460..63984 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2I0C738
Locus tag NOV18_RS27895 Protein ID WP_010792483.1
Coordinates 63068..63463 (+) Length 132 a.a.

Genomic Context

NOV18_RS27890NOV18_RS27895NOV18_RS27900NOV18_RS27915NOV18_RS27920NOV18_RS27880NOV18_RS27885NOV18_RS27905NOV18_RS27910NOV18_RS27925
Location: 60924..62858 (1935 bp)
Type: Others
Protein ID: WP_021018401.1
Location: 63068..63463 (396 bp)
Type: Antitoxin
Protein ID: WP_010792483.1
Location: 63460..63984 (525 bp)
Type: Toxin
Protein ID: WP_021018402.1
Location: 66910..67101 (192 bp)
Type: Others
Protein ID: WP_010792486.1
Location: 67172..67426 (255 bp)
Type: Others
Protein ID: WP_010792487.1
Location: 59091..59615 (525 bp)
Type: Others
Protein ID: WP_010792479.1
Location: 60494..60775 (282 bp)
Type: Others
Protein ID: WP_010792481.1
Location: 64030..65280 (1251 bp)
Type: Others
Protein ID: WP_010792484.1
Location: 65477..66532 (1056 bp)
Type: Others
Protein ID: WP_021018403.1
Location: 67523..68668 (1146 bp)
Type: Others
Protein ID: WP_021018404.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NOV18_RS27880 (NOV18_27880)59091..59615-525WP_010792479.1hypothetical protein-
NOV18_RS27885 (NOV18_27885)60494..60775-282WP_010792481.1hypothetical protein-
NOV18_RS27890 (NOV18_27890)60924..62858+1935WP_021018401.1hypothetical protein-
NOV18_RS27895 (NOV18_27895)63068..63463+396WP_010792483.1hypothetical proteinAntitoxin
NOV18_RS27900 (NOV18_27900)63460..63984+525WP_021018402.1RES family NAD+ phosphorylaseToxin
NOV18_RS27905 (NOV18_27905)64030..65280-1251WP_010792484.1TerD family protein-
NOV18_RS27910 (NOV18_27910)65477..66532-1056WP_021018403.1prepilin-type N-terminal cleavage/methylation domain-containing protein-
NOV18_RS27915 (NOV18_27915)66910..67101+192WP_010792486.1hypothetical protein-
NOV18_RS27920 (NOV18_27920)67172..67426+255WP_010792487.1hypothetical protein-
NOV18_RS27925 (NOV18_27925)67523..68668-1146WP_021018404.1glycerate kinase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidaph(3')-VI / msr(E) / mph(E) / aac(6')-IIa / cmlA1 / blaOXA-246 / ARR-3 / dfrA27 / qacE / sul1 / blaNDM-14 / aac(6')-Il / aadA1 / aph(3'')-Ib / aph(6)-Id / mph(A) / aac(3)-IId / dfrA22 / qnrVC1-1..455169455169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19011.47 Da        Isoelectric Point: 4.4540

>T252511 WP_021018402.1 NZ_CP101701:63460-63984 [Pseudomonas asiatica]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14810.93 Da        Isoelectric Point: 7.2048

>AT252511 WP_010792483.1 NZ_CP101701:63068-63463 [Pseudomonas asiatica]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A212BIN6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2I0C738

References