Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 63068..63984 | Replicon | plasmid pMD9A |
| Accession | NZ_CP101701 | ||
| Organism | Pseudomonas asiatica strain MD9 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A212BIN6 |
| Locus tag | NOV18_RS27900 | Protein ID | WP_021018402.1 |
| Coordinates | 63460..63984 (+) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A2I0C738 |
| Locus tag | NOV18_RS27895 | Protein ID | WP_010792483.1 |
| Coordinates | 63068..63463 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NOV18_RS27880 (NOV18_27880) | 59091..59615 | - | 525 | WP_010792479.1 | hypothetical protein | - |
| NOV18_RS27885 (NOV18_27885) | 60494..60775 | - | 282 | WP_010792481.1 | hypothetical protein | - |
| NOV18_RS27890 (NOV18_27890) | 60924..62858 | + | 1935 | WP_021018401.1 | hypothetical protein | - |
| NOV18_RS27895 (NOV18_27895) | 63068..63463 | + | 396 | WP_010792483.1 | hypothetical protein | Antitoxin |
| NOV18_RS27900 (NOV18_27900) | 63460..63984 | + | 525 | WP_021018402.1 | RES family NAD+ phosphorylase | Toxin |
| NOV18_RS27905 (NOV18_27905) | 64030..65280 | - | 1251 | WP_010792484.1 | TerD family protein | - |
| NOV18_RS27910 (NOV18_27910) | 65477..66532 | - | 1056 | WP_021018403.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| NOV18_RS27915 (NOV18_27915) | 66910..67101 | + | 192 | WP_010792486.1 | hypothetical protein | - |
| NOV18_RS27920 (NOV18_27920) | 67172..67426 | + | 255 | WP_010792487.1 | hypothetical protein | - |
| NOV18_RS27925 (NOV18_27925) | 67523..68668 | - | 1146 | WP_021018404.1 | glycerate kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(3')-VI / msr(E) / mph(E) / aac(6')-IIa / cmlA1 / blaOXA-246 / ARR-3 / dfrA27 / qacE / sul1 / blaNDM-14 / aac(6')-Il / aadA1 / aph(3'')-Ib / aph(6)-Id / mph(A) / aac(3)-IId / dfrA22 / qnrVC1 | - | 1..455169 | 455169 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 19011.47 Da Isoelectric Point: 4.4540
>T252511 WP_021018402.1 NZ_CP101701:63460-63984 [Pseudomonas asiatica]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
Download Length: 525 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14810.93 Da Isoelectric Point: 7.2048
>AT252511 WP_010792483.1 NZ_CP101701:63068-63463 [Pseudomonas asiatica]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A212BIN6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I0C738 |