Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3822234..3823273 | Replicon | chromosome |
| Accession | NZ_CP101700 | ||
| Organism | Pseudomonas asiatica strain MD9 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | A0A2N5BP56 |
| Locus tag | NOV18_RS17805 | Protein ID | WP_015271072.1 |
| Coordinates | 3822698..3823273 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A2N5BP88 |
| Locus tag | NOV18_RS17800 | Protein ID | WP_015271071.1 |
| Coordinates | 3822234..3822701 (+) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NOV18_RS17775 (NOV18_17775) | 3817293..3818366 | + | 1074 | WP_009686399.1 | microcin C ABC transporter permease YejB | - |
| NOV18_RS17780 (NOV18_17780) | 3818368..3819387 | + | 1020 | WP_013973404.1 | ABC transporter permease | - |
| NOV18_RS17785 (NOV18_17785) | 3819389..3820999 | + | 1611 | WP_054572484.1 | ABC transporter ATP-binding protein | - |
| NOV18_RS17790 (NOV18_17790) | 3821390..3821632 | + | 243 | WP_054572483.1 | hypothetical protein | - |
| NOV18_RS17795 (NOV18_17795) | 3821789..3822052 | + | 264 | WP_015271070.1 | DUF3077 domain-containing protein | - |
| NOV18_RS17800 (NOV18_17800) | 3822234..3822701 | + | 468 | WP_015271071.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NOV18_RS17805 (NOV18_17805) | 3822698..3823273 | + | 576 | WP_015271072.1 | PIN domain-containing protein | Toxin |
| NOV18_RS17810 (NOV18_17810) | 3823488..3826418 | + | 2931 | WP_015271073.1 | aminotransferase | - |
| NOV18_RS17815 (NOV18_17815) | 3826782..3827687 | + | 906 | WP_013973410.1 | LysR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3801200..3826418 | 25218 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21970.23 Da Isoelectric Point: 5.0798
>T252510 WP_015271072.1 NZ_CP101700:3822698-3823273 [Pseudomonas asiatica]
MKHSPFTAIYDANVLYPAPLRDFLMNLALTGIYRARWSTKIHDEWKRNLLLNRPDLTLEQVDRTSRRMDAAVPDALVTDY
ESLVEGLDLPDKDDRHVLAAAIKCNASVIVTFNLKDFPETALDVFDIEPLHPDDFIADLWDLDKAAVLEAAQRQRMSLKN
PPHSVQQYLDRLLQQKLPESVKLLSEFKFLL
MKHSPFTAIYDANVLYPAPLRDFLMNLALTGIYRARWSTKIHDEWKRNLLLNRPDLTLEQVDRTSRRMDAAVPDALVTDY
ESLVEGLDLPDKDDRHVLAAAIKCNASVIVTFNLKDFPETALDVFDIEPLHPDDFIADLWDLDKAAVLEAAQRQRMSLKN
PPHSVQQYLDRLLQQKLPESVKLLSEFKFLL
Download Length: 576 bp
Antitoxin
Download Length: 156 a.a. Molecular weight: 17366.86 Da Isoelectric Point: 5.3408
>AT252510 WP_015271071.1 NZ_CP101700:3822234-3822701 [Pseudomonas asiatica]
MTTADLSRKMLPDEKEIAVAVESSRTLAAFLSTKSDTQRIELLNEENQRQVVEVPTFALRLFGEILSELALGNSVKVVPI
HAELTTQEAADLLNVSRPYLVKLLDESVIPHTKTGRHRRVKFSDLVAYKDKRDEVSRAAMDALAAEAQELRMGYE
MTTADLSRKMLPDEKEIAVAVESSRTLAAFLSTKSDTQRIELLNEENQRQVVEVPTFALRLFGEILSELALGNSVKVVPI
HAELTTQEAADLLNVSRPYLVKLLDESVIPHTKTGRHRRVKFSDLVAYKDKRDEVSRAAMDALAAEAQELRMGYE
Download Length: 468 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N5BP56 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N5BP88 |