252506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 4825845..4826367 Replicon chromosome
Accession NZ_CP101689
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NOV91_RS23470 Protein ID WP_000221345.1
Coordinates 4825845..4826129 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NOV91_RS23475 Protein ID WP_000885424.1
Coordinates 4826119..4826367 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV91_RS23450 (4821920) 4821920..4823428 - 1509 WP_017441357.1 FAD-dependent oxidoreductase -
NOV91_RS23455 (4823473) 4823473..4823961 + 489 WP_017441356.1 MarR family winged helix-turn-helix transcriptional regulator -
NOV91_RS23460 (4824154) 4824154..4825227 + 1074 WP_017441355.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NOV91_RS23465 (4825285) 4825285..4825674 - 390 WP_001652798.1 RidA family protein -
NOV91_RS23470 (4825845) 4825845..4826129 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOV91_RS23475 (4826119) 4826119..4826367 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NOV91_RS23480 (4826780) 4826780..4827133 - 354 WP_000418733.1 hypothetical protein -
NOV91_RS23485 (4827136) 4827136..4827525 - 390 WP_017441353.1 hypothetical protein -
NOV91_RS23490 (4827890) 4827890..4828006 + 117 Protein_4579 IS110 family transposase -
NOV91_RS23495 (4828529) 4828529..4828861 + 333 WP_017441352.1 DUF1493 family protein -
NOV91_RS23500 (4829134) 4829134..4830042 + 909 WP_077906523.1 hypothetical protein -
NOV91_RS23505 (4830044) 4830044..4830824 - 781 Protein_4582 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4824154..4835573 11419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T252506 WP_000221345.1 NZ_CP101689:c4826129-4825845 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT252506 WP_000885424.1 NZ_CP101689:c4826367-4826119 [Salmonella enterica subsp. enterica serovar Mbandaka]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References