Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3794107..3794727 Replicon chromosome
Accession NZ_CP101689
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NOV91_RS18370 Protein ID WP_001280991.1
Coordinates 3794107..3794325 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NOV91_RS18375 Protein ID WP_000344807.1
Coordinates 3794353..3794727 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV91_RS18330 (3789332) 3789332..3789901 + 570 WP_000779801.1 YbaY family lipoprotein -
NOV91_RS18335 (3789934) 3789934..3790323 - 390 WP_000961285.1 MGMT family protein -
NOV91_RS18345 (3790554) 3790554..3792104 - 1551 WP_000213140.1 EAL domain-containing protein -
NOV91_RS18350 (3792329) 3792329..3792589 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NOV91_RS18355 (3792595) 3792595..3792735 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NOV91_RS18360 (3792791) 3792791..3793261 - 471 WP_000136183.1 YlaC family protein -
NOV91_RS18365 (3793377) 3793377..3793928 - 552 WP_001278793.1 maltose O-acetyltransferase -
NOV91_RS18370 (3794107) 3794107..3794325 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NOV91_RS18375 (3794353) 3794353..3794727 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NOV91_RS18380 (3795223) 3795223..3798372 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NOV91_RS18385 (3798395) 3798395..3799588 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T252505 WP_001280991.1 NZ_CP101689:c3794325-3794107 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT252505 WP_000344807.1 NZ_CP101689:c3794727-3794353 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References