Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3093028..3093671 Replicon chromosome
Accession NZ_CP101689
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NOV91_RS15085 Protein ID WP_017441191.1
Coordinates 3093028..3093444 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag NOV91_RS15090 Protein ID WP_001261294.1
Coordinates 3093441..3093671 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV91_RS15065 (3088065) 3088065..3089198 + 1134 WP_017441192.1 amidohydrolase/deacetylase family metallohydrolase -
NOV91_RS15070 (3089182) 3089182..3090300 + 1119 WP_001139194.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NOV91_RS15075 (3090297) 3090297..3091037 + 741 WP_023229489.1 KDGP aldolase family protein -
NOV91_RS15080 (3091054) 3091054..3092967 + 1914 WP_023242878.1 BglG family transcription antiterminator -
NOV91_RS15085 (3093028) 3093028..3093444 - 417 WP_017441191.1 type II toxin-antitoxin system VapC family toxin Toxin
NOV91_RS15090 (3093441) 3093441..3093671 - 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NOV91_RS15095 (3093838) 3093838..3094302 - 465 WP_017441190.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NOV91_RS15100 (3094519) 3094519..3096657 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15163.55 Da        Isoelectric Point: 8.1381

>T252497 WP_017441191.1 NZ_CP101689:c3093444-3093028 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAVGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT252497 WP_001261294.1 NZ_CP101689:c3093671-3093441 [Salmonella enterica subsp. enterica serovar Mbandaka]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References