Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2948212..2948993 Replicon chromosome
Accession NZ_CP101689
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag NOV91_RS14345 Protein ID WP_000625911.1
Coordinates 2948502..2948993 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag NOV91_RS14340 Protein ID WP_001271379.1
Coordinates 2948212..2948505 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV91_RS14305 (2944514) 2944514..2945419 + 906 WP_001268200.1 YjiK family protein -
NOV91_RS14310 (2945713) 2945713..2945907 - 195 WP_223195369.1 hypothetical protein -
NOV91_RS14315 (2945955) 2945955..2946054 - 100 Protein_2784 hypothetical protein -
NOV91_RS14320 (2946074) 2946074..2946241 + 168 WP_071527476.1 ATP-binding cassette domain-containing protein -
NOV91_RS14325 (2946248) 2946248..2946535 - 288 WP_072103482.1 transcriptional regulator RtsB -
NOV91_RS14330 (2946532) 2946532..2947407 - 876 WP_017441228.1 AraC family transcriptional regulator -
NOV91_RS14335 (2947673) 2947673..2947894 - 222 WP_001595143.1 hypothetical protein -
NOV91_RS14340 (2948212) 2948212..2948505 + 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
NOV91_RS14345 (2948502) 2948502..2948993 + 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
NOV91_RS14350 (2949208) 2949208..2949456 + 249 Protein_2791 IS481 family transposase -
NOV91_RS14355 (2949702) 2949702..2949959 - 258 WP_001112996.1 hypothetical protein -
NOV91_RS14360 (2950553) 2950553..2950837 + 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
NOV91_RS14365 (2950872) 2950872..2951411 + 540 WP_000721295.1 type 1 fimbrial protein -
NOV91_RS14370 (2951421) 2951421..2953859 + 2439 WP_017441226.1 F4 (K88) fimbrial usher FaeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeC / faeD / faeE / faeF / faeH / faeI 2946532..2961487 14955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T252496 WP_000625911.1 NZ_CP101689:2948502-2948993 [Salmonella enterica subsp. enterica serovar Mbandaka]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT252496 WP_001271379.1 NZ_CP101689:2948212-2948505 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References