Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2090137..2090928 Replicon chromosome
Accession NZ_CP101689
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag NOV91_RS10335 Protein ID WP_000369560.1
Coordinates 2090137..2090655 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag NOV91_RS10340 Protein ID WP_001275017.1
Coordinates 2090659..2090928 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV91_RS10310 (2085202) 2085202..2085969 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NOV91_RS10315 (2085966) 2085966..2087243 - 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
NOV91_RS10320 (2087240) 2087240..2088166 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NOV91_RS10325 (2088226) 2088226..2089335 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NOV91_RS10330 (2089757) 2089757..2090140 + 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
NOV91_RS10335 (2090137) 2090137..2090655 - 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
NOV91_RS10340 (2090659) 2090659..2090928 - 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
NOV91_RS10345 (2091106) 2091106..2092209 - 1104 WP_001528146.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NOV91_RS10350 (2092531) 2092531..2093385 - 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
NOV91_RS10355 (2093631) 2093631..2094686 - 1056 WP_001081707.1 permease-like cell division protein FtsX -
NOV91_RS10360 (2094679) 2094679..2095347 - 669 WP_000617729.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T252493 WP_000369560.1 NZ_CP101689:c2090655-2090137 [Salmonella enterica subsp. enterica serovar Mbandaka]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT252493 WP_001275017.1 NZ_CP101689:c2090928-2090659 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References