Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1567050..1567710 Replicon chromosome
Accession NZ_CP101689
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)


Gene name cptA Uniprot ID A0A3V4SJP5
Locus tag NOV91_RS07735 Protein ID WP_000244755.1
Coordinates 1567050..1567463 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NOV91_RS07740 Protein ID WP_000351186.1
Coordinates 1567444..1567710 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV91_RS07715 (1562991) 1562991..1564724 - 1734 WP_000813392.1 single-stranded-DNA-specific exonuclease RecJ -
NOV91_RS07720 (1564730) 1564730..1565443 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NOV91_RS07725 (1565467) 1565467..1566363 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NOV91_RS07730 (1566476) 1566476..1566997 + 522 WP_017441091.1 flavodoxin FldB -
NOV91_RS07735 (1567050) 1567050..1567463 - 414 WP_000244755.1 protein YgfX Toxin
NOV91_RS07740 (1567444) 1567444..1567710 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NOV91_RS07745 (1567960) 1567960..1568940 + 981 WP_017441090.1 tRNA-modifying protein YgfZ -
NOV91_RS07750 (1569056) 1569056..1569715 - 660 WP_000250289.1 hemolysin III family protein -
NOV91_RS07755 (1569879) 1569879..1570190 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NOV91_RS07760 (1570348) 1570348..1571781 + 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16164.10 Da        Isoelectric Point: 10.2118

>T252490 WP_000244755.1 NZ_CP101689:c1567463-1567050 [Salmonella enterica subsp. enterica serovar Mbandaka]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT252490 WP_000351186.1 NZ_CP101689:c1567710-1567444 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SJP5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References