252489

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1408690..1409504 Replicon chromosome
Accession NZ_CP101689
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3W0Q3Z8
Locus tag NOV91_RS07015 Protein ID WP_017441137.1
Coordinates 1408977..1409504 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A418Z520
Locus tag NOV91_RS07010 Protein ID WP_017441138.1
Coordinates 1408690..1408980 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV91_RS06980 (1404618) 1404618..1405268 - 651 WP_001728903.1 type III secretion system transcriptional activator InvF -
NOV91_RS06985 (1405724) 1405724..1406167 + 444 WP_017441140.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NOV91_RS06990 (1406599) 1406599..1407048 + 450 WP_017441139.1 hypothetical protein -
NOV91_RS06995 (1407033) 1407033..1407380 + 348 WP_001555786.1 DUF1493 family protein -
NOV91_RS07000 (1407653) 1407653..1407979 - 327 WP_000393295.1 hypothetical protein -
NOV91_RS07005 (1408220) 1408220..1408420 + 201 Protein_1370 IS3 family transposase -
NOV91_RS07010 (1408690) 1408690..1408980 + 291 WP_017441138.1 DUF1778 domain-containing protein Antitoxin
NOV91_RS07015 (1408977) 1408977..1409504 + 528 WP_017441137.1 GNAT family N-acetyltransferase Toxin
NOV91_RS07020 (1409577) 1409577..1409792 - 216 Protein_1373 IS5/IS1182 family transposase -
NOV91_RS07025 (1410130) 1410130..1410786 + 657 WP_017441135.1 protein-serine/threonine phosphatase -
NOV91_RS07030 (1410957) 1410957..1411451 - 495 WP_000424947.1 hypothetical protein -
NOV91_RS07035 (1411478) 1411478..1412146 - 669 WP_000445914.1 hypothetical protein -
NOV91_RS07040 (1412303) 1412303..1412542 - 240 Protein_1377 hypothetical protein -
NOV91_RS07045 (1412733) 1412733..1413131 - 399 Protein_1378 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1409577..1409717 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19035.89 Da        Isoelectric Point: 9.6420

>T252489 WP_017441137.1 NZ_CP101689:1408977-1409504 [Salmonella enterica subsp. enterica serovar Mbandaka]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SLKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10721.55 Da        Isoelectric Point: 8.5957

>AT252489 WP_017441138.1 NZ_CP101689:1408690-1408980 [Salmonella enterica subsp. enterica serovar Mbandaka]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFARPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W0Q3Z8

Antitoxin

Source ID Structure
AlphaFold DB A0A418Z520

References