Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 39019..39541 Replicon plasmid pM171-1.2
Accession NZ_CP101668
Organism Escherichia coli strain M171-1

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag NO473_RS23180 Protein ID WP_000220561.1
Coordinates 39019..39300 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag NO473_RS23185 Protein ID WP_000121743.1
Coordinates 39290..39541 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO473_RS23150 (34495) 34495..34731 - 237 Protein_41 hypothetical protein -
NO473_RS23155 (34752) 34752..35546 - 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
NO473_RS23160 (35575) 35575..37005 - 1431 Protein_43 IS4-like element IS50R family transposase -
NO473_RS23165 (37125) 37125..37313 + 189 WP_000957857.1 hypothetical protein -
NO473_RS23170 (37323) 37323..38522 + 1200 WP_000948429.1 IS91 family transposase -
NO473_RS23175 (38688) 38688..38780 + 93 Protein_46 IS6 family transposase -
NO473_RS23180 (39019) 39019..39300 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NO473_RS23185 (39290) 39290..39541 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
NO473_RS23190 (40776) 40776..41615 + 840 WP_024129959.1 replication initiation protein -
NO473_RS23195 (41636) 41636..42478 + 843 WP_063116919.1 replication initiation protein -
NO473_RS23200 (42482) 42482..42928 + 447 WP_001074384.1 hypothetical protein -
NO473_RS23205 (43065) 43065..43418 + 354 WP_024129958.1 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCTX-M-65 / dfrA14 / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / tet(A) / aph(3')-IIa / blaTEM-1B / qepA1 - 1..72916 72916


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T252483 WP_000220561.1 NZ_CP101668:c39300-39019 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT252483 WP_000121743.1 NZ_CP101668:c39541-39290 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References