Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 513080..513651 Replicon chromosome
Accession NC_015566
Organism Serratia sp. AS12

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3YYL5
Locus tag SERAS12_RS02410 Protein ID WP_013811308.1
Coordinates 513376..513651 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag SERAS12_RS02405 Protein ID WP_013811307.1
Coordinates 513080..513367 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS12_RS02380 508782..509867 - 1086 WP_013811302.1 carbon-phosphorus lyase complex subunit PhnI -
SERAS12_RS02385 509867..510448 - 582 WP_013811303.1 phosphonate C-P lyase system protein PhnH -
SERAS12_RS02390 510452..510895 - 444 WP_013811304.1 phosphonate C-P lyase system protein PhnG -
SERAS12_RS02395 510896..511621 - 726 WP_174270197.1 phosphonate metabolism transcriptional regulator PhnF -
SERAS12_RS02400 511916..512974 + 1059 WP_013811306.1 permease -
SERAS12_RS02405 513080..513367 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SERAS12_RS02410 513376..513651 + 276 WP_013811308.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
SERAS12_RS02415 513655..514119 - 465 WP_013811309.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
SERAS12_RS02420 514288..516426 - 2139 WP_013811310.1 anaerobic ribonucleoside-triphosphate reductase -
SERAS12_RS02425 516641..517546 - 906 WP_013811311.1 LysR family transcriptional regulator -
SERAS12_RS02430 517651..518175 + 525 WP_013811312.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10712.50 Da        Isoelectric Point: 9.6236

>T25248 WP_013811308.1 NC_015566:513376-513651 [Serratia sp. AS12]
MRIEWDNAALRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLEHPELGKTWHGKARKLLINKASLLLVYIIVDDVIKVF
AIAHQREKFPN

Download         Length: 276 bp

>T25248 NC_015566:513376-513651 [Serratia sp. AS12]
ATGCGTATCGAATGGGATAATGCAGCGCTACGGGACAGGGAACGTATTTTTGAGTTTCTTTATATTTTCAATCCACAGGC
GGCAGTGCAGGCTGATAACGAGATAGATAAAGCGGTAAAGCGCCTGCTGGAGCATCCTGAGTTAGGTAAGACCTGGCATG
GGAAGGCGCGTAAGCTGCTTATTAATAAGGCCTCTCTGTTGCTGGTATATATCATCGTCGATGATGTTATTAAGGTTTTC
GCGATTGCTCACCAGCGCGAGAAATTTCCAAACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT25248 WP_013811307.1 NC_015566:513080-513367 [Serratia sp. AS12]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp

>AT25248 NC_015566:513080-513367 [Serratia sp. AS12]
ATGGAAAGTCGTATCCAGTTTCGCATCGAAGATGAAACCAAGCGTTTGGCGCAAAAGGCCGCTGAAGCTAAAGGGACGAC
ATTAAGTGAAGCCTGTCGCCGCTTGGCGGAGCAAATGGCTGATGAGCAACGGGCAGCGGAAGAGCACGAAAACTGGTTGA
AAGATAAGGTAGATGCAGCTTTTTCCCGTCTGCATGAGGGCAATGCTGTCTACCTTAGCCAACAAGAAGTTGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAATCAGAGCGAAATACGACCGAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3YYL5

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References