Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2466883..2467718 Replicon chromosome
Accession NZ_CP101666
Organism Escherichia coli strain M171-1

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag NO473_RS12105 Protein ID WP_057109034.1
Coordinates 2467341..2467718 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1E5MC43
Locus tag NO473_RS12100 Protein ID WP_063112944.1
Coordinates 2466883..2467251 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO473_RS12060 (2462060) 2462060..2462944 + 885 WP_023563932.1 50S ribosome-binding GTPase -
NO473_RS12065 (2463063) 2463063..2463740 + 678 WP_063091580.1 hypothetical protein -
NO473_RS12070 (2463746) 2463746..2463898 + 153 WP_001696589.1 DUF905 family protein -
NO473_RS12075 (2463999) 2463999..2464817 + 819 WP_096211214.1 DUF932 domain-containing protein -
NO473_RS12080 (2464909) 2464909..2465394 + 486 WP_000213716.1 antirestriction protein -
NO473_RS12085 (2465410) 2465410..2465886 + 477 WP_001186780.1 RadC family protein -
NO473_RS12090 (2465949) 2465949..2466170 + 222 WP_000692323.1 DUF987 domain-containing protein -
NO473_RS12095 (2466189) 2466189..2466833 + 645 WP_045146861.1 hypothetical protein -
NO473_RS12100 (2466883) 2466883..2467251 + 369 WP_063112944.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NO473_RS12105 (2467341) 2467341..2467718 + 378 WP_057109034.1 TA system toxin CbtA family protein Toxin
NO473_RS12110 (2467715) 2467715..2467864 + 150 Protein_2363 DUF5983 family protein -
NO473_RS12115 (2467940) 2467940..2468137 + 198 WP_023563519.1 DUF957 domain-containing protein -
NO473_RS12120 (2468222) 2468222..2469064 + 843 WP_001529559.1 DUF4942 domain-containing protein -
NO473_RS12125 (2469813) 2469813..2471351 + 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2455622..2479164 23542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13934.86 Da        Isoelectric Point: 6.8517

>T252467 WP_057109034.1 NZ_CP101666:2467341-2467718 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13724.52 Da        Isoelectric Point: 6.8270

>AT252467 WP_063112944.1 NZ_CP101666:2466883-2467251 [Escherichia coli]
VSDTLPGTTHHDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E5MC43

References