Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1768387..1769005 Replicon chromosome
Accession NZ_CP101666
Organism Escherichia coli strain M171-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NO473_RS08685 Protein ID WP_001291435.1
Coordinates 1768787..1769005 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NO473_RS08680 Protein ID WP_000344800.1
Coordinates 1768387..1768761 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO473_RS08670 (1763476) 1763476..1764669 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NO473_RS08675 (1764692) 1764692..1767841 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NO473_RS08680 (1768387) 1768387..1768761 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NO473_RS08685 (1768787) 1768787..1769005 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NO473_RS08690 (1769177) 1769177..1769728 + 552 WP_000102564.1 maltose O-acetyltransferase -
NO473_RS08695 (1769844) 1769844..1770314 + 471 WP_000136192.1 YlaC family protein -
NO473_RS08700 (1770478) 1770478..1772028 + 1551 WP_072643403.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NO473_RS08705 (1772070) 1772070..1772423 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NO473_RS08715 (1772802) 1772802..1773113 + 312 WP_165369371.1 MGMT family protein -
NO473_RS08720 (1773144) 1773144..1773716 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T252463 WP_001291435.1 NZ_CP101666:1768787-1769005 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT252463 WP_000344800.1 NZ_CP101666:1768387-1768761 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References