Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 742727..743365 Replicon chromosome
Accession NZ_CP101666
Organism Escherichia coli strain M171-1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NO473_RS03600 Protein ID WP_000813794.1
Coordinates 743189..743365 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NO473_RS03595 Protein ID WP_001270286.1
Coordinates 742727..743143 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO473_RS03575 (737879) 737879..738820 - 942 WP_001251313.1 ABC transporter permease -
NO473_RS03580 (738821) 738821..739834 - 1014 WP_072643648.1 ABC transporter ATP-binding protein -
NO473_RS03585 (739852) 739852..740997 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NO473_RS03590 (741242) 741242..742648 - 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
NO473_RS03595 (742727) 742727..743143 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NO473_RS03600 (743189) 743189..743365 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NO473_RS03605 (743587) 743587..743817 + 231 WP_000494244.1 YncJ family protein -
NO473_RS03610 (743909) 743909..745870 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NO473_RS03615 (745943) 745943..746479 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
NO473_RS03620 (746571) 746571..747746 + 1176 WP_001236251.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 747786..749051 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T252462 WP_000813794.1 NZ_CP101666:c743365-743189 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT252462 WP_001270286.1 NZ_CP101666:c743143-742727 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References