252455

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1220065..1220982 Replicon chromosome
Accession NZ_CP101661
Organism Bacillus amyloliquefaciens strain B408

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag NO220_RS06395 Protein ID WP_025851786.1
Coordinates 1220236..1220982 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag NO220_RS06390 Protein ID WP_003154807.1
Coordinates 1220065..1220235 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO220_RS06350 (NO220_06350) 1215296..1216918 + 1623 WP_003154821.1 pyocin knob domain-containing protein -
NO220_RS06355 (NO220_06355) 1216931..1217302 + 372 WP_014304856.1 XkdW family protein -
NO220_RS06360 (NO220_06360) 1217308..1217505 + 198 WP_003154819.1 XkdX family protein -
NO220_RS06365 (NO220_06365) 1217562..1218323 + 762 WP_043867020.1 hypothetical protein -
NO220_RS06370 (NO220_06370) 1218375..1218638 + 264 WP_003154815.1 hemolysin XhlA family protein -
NO220_RS06375 (NO220_06375) 1218652..1218915 + 264 WP_003154813.1 phage holin -
NO220_RS06380 (NO220_06380) 1218929..1219807 + 879 WP_025851788.1 N-acetylmuramoyl-L-alanine amidase -
NO220_RS06385 (NO220_06385) 1219843..1219968 - 126 WP_003154809.1 hypothetical protein -
NO220_RS06390 (NO220_06390) 1220065..1220235 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NO220_RS06395 (NO220_06395) 1220236..1220982 - 747 WP_025851786.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NO220_RS06400 (NO220_06400) 1221087..1222085 - 999 WP_003154805.1 inorganic phosphate transporter -
NO220_RS06405 (NO220_06405) 1222098..1222715 - 618 WP_003154804.1 DUF47 domain-containing protein -
NO220_RS06410 (NO220_06410) 1223001..1224317 - 1317 WP_003154801.1 amino acid permease -
NO220_RS06415 (NO220_06415) 1224640..1225590 + 951 WP_043867021.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29048.53 Da        Isoelectric Point: 4.7003

>T252455 WP_025851786.1 NZ_CP101661:c1220982-1220236 [Bacillus amyloliquefaciens]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CEYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT252455 WP_003154807.1 NZ_CP101661:c1220235-1220065 [Bacillus amyloliquefaciens]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References