252452

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5718578..5719186 Replicon chromosome
Accession NZ_CP101656
Organism Pseudomonas aeruginosa strain L1a

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag MBA02_RS26435 Protein ID WP_003114156.1
Coordinates 5718578..5718925 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag MBA02_RS26440 Protein ID WP_003114155.1
Coordinates 5718935..5719186 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA02_RS26405 (MBA02_026405) 5713937..5714209 + 273 WP_010895521.1 cysteine-rich CWC family protein -
MBA02_RS26410 (MBA02_026410) 5714209..5714901 + 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
MBA02_RS26415 (MBA02_026415) 5715037..5716080 + 1044 WP_003098363.1 L,D-transpeptidase -
MBA02_RS26420 (MBA02_026420) 5716160..5716897 + 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
MBA02_RS26425 (MBA02_026425) 5717349..5718251 + 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
MBA02_RS26435 (MBA02_026435) 5718578..5718925 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MBA02_RS26440 (MBA02_026440) 5718935..5719186 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MBA02_RS26445 (MBA02_026445) 5719400..5720383 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
MBA02_RS26450 (MBA02_026450) 5720383..5721675 - 1293 WP_003115206.1 hypothetical protein -
MBA02_RS26455 (MBA02_026455) 5721905..5723179 - 1275 WP_010895520.1 zonular occludens toxin family protein -
MBA02_RS26460 (MBA02_026460) 5723183..5723539 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5718578..5746954 28376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T252452 WP_003114156.1 NZ_CP101656:c5718925-5718578 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT252452 WP_003114155.1 NZ_CP101656:c5719186-5718935 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References