Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5398783..5400041 Replicon chromosome
Accession NZ_CP101656
Organism Pseudomonas aeruginosa strain L1a

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag MBA02_RS24850 Protein ID WP_003112528.1
Coordinates 5398783..5399538 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag MBA02_RS24855 Protein ID WP_003086329.1
Coordinates 5399673..5400041 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA02_RS24840 (MBA02_024840) 5393956..5396499 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
MBA02_RS24845 (MBA02_024845) 5396654..5398015 - 1362 WP_010895536.1 DNA recombination protein RmuC -
MBA02_RS24850 (MBA02_024850) 5398783..5399538 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
MBA02_RS24855 (MBA02_024855) 5399673..5400041 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
MBA02_RS24860 (MBA02_024860) 5400114..5401400 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
MBA02_RS24865 (MBA02_024865) 5401456..5403045 - 1590 WP_010895535.1 aldehyde dehydrogenase family protein -
MBA02_RS24870 (MBA02_024870) 5403124..5403600 + 477 WP_003112531.1 hypothetical protein -
MBA02_RS24875 (MBA02_024875) 5403603..5403878 - 276 WP_010793902.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T252451 WP_003112528.1 NZ_CP101656:c5399538-5398783 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT252451 WP_003086329.1 NZ_CP101656:c5400041-5399673 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References