Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2856389..2857897 Replicon chromosome
Accession NZ_CP101656
Organism Pseudomonas aeruginosa strain L1a

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag MBA02_RS13215 Protein ID WP_003119682.1
Coordinates 2856389..2856976 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9HYX2
Locus tag MBA02_RS13220 Protein ID WP_003115566.1
Coordinates 2857043..2857897 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA02_RS13210 (MBA02_013210) 2852644..2856123 - 3480 WP_003114080.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
MBA02_RS13215 (MBA02_013215) 2856389..2856976 + 588 WP_003119682.1 GNAT family protein Toxin
MBA02_RS13220 (MBA02_013220) 2857043..2857897 + 855 WP_003115566.1 AraC family transcriptional regulator Antitoxin
MBA02_RS13225 (MBA02_013225) 2857994..2860159 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
MBA02_RS13230 (MBA02_013230) 2860334..2862208 + 1875 WP_003091605.1 MFS transporter -
MBA02_RS13235 (MBA02_013235) 2862269..2862478 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T252449 WP_003119682.1 NZ_CP101656:2856389-2856976 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31933.23 Da        Isoelectric Point: 7.3276

>AT252449 WP_003115566.1 NZ_CP101656:2857043-2857897 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB Q9HYX2

References