Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2589906..2591601 Replicon chromosome
Accession NZ_CP101656
Organism Pseudomonas aeruginosa strain L1a

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag MBA02_RS11975 Protein ID WP_003112901.1
Coordinates 2589906..2590775 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag MBA02_RS11980 Protein ID WP_003112902.1
Coordinates 2590768..2591601 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA02_RS11950 (MBA02_011950) 2585914..2586765 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
MBA02_RS11955 (MBA02_011955) 2586806..2587813 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
MBA02_RS11960 (MBA02_011960) 2587810..2588586 + 777 WP_003112898.1 ABC transporter permease -
MBA02_RS11965 (MBA02_011965) 2588592..2589353 + 762 WP_003112899.1 SDR family oxidoreductase -
MBA02_RS11970 (MBA02_011970) 2589367..2589897 + 531 WP_003112900.1 cupin domain-containing protein -
MBA02_RS11975 (MBA02_011975) 2589906..2590775 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
MBA02_RS11980 (MBA02_011980) 2590768..2591601 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
MBA02_RS11985 (MBA02_011985) 2591588..2592385 + 798 WP_003112903.1 SDR family oxidoreductase -
MBA02_RS11990 (MBA02_011990) 2592378..2594060 + 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
MBA02_RS11995 (MBA02_011995) 2594071..2594874 + 804 WP_003112905.1 aspartate dehydrogenase -
MBA02_RS12000 (MBA02_012000) 2594886..2596370 + 1485 WP_003112906.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T252448 WP_003112901.1 NZ_CP101656:2589906-2590775 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT252448 WP_003112902.1 NZ_CP101656:2590768-2591601 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References