Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1143876..1144381 Replicon chromosome
Accession NZ_CP101656
Organism Pseudomonas aeruginosa strain L1a

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag MBA02_RS05225 Protein ID WP_003083773.1
Coordinates 1143876..1144157 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag MBA02_RS05230 Protein ID WP_003112628.1
Coordinates 1144154..1144381 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA02_RS05200 (MBA02_005200) 1139127..1140476 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
MBA02_RS05205 (MBA02_005205) 1140525..1141211 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
MBA02_RS05210 (MBA02_005210) 1141312..1142046 + 735 WP_003115036.1 GntR family transcriptional regulator -
MBA02_RS05215 (MBA02_005215) 1142226..1142636 + 411 WP_003101225.1 aegerolysin family protein -
MBA02_RS05220 (MBA02_005220) 1142668..1143576 - 909 WP_003083769.1 LysR family transcriptional regulator -
MBA02_RS05225 (MBA02_005225) 1143876..1144157 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
MBA02_RS05230 (MBA02_005230) 1144154..1144381 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
MBA02_RS05235 (MBA02_005235) 1144557..1145177 - 621 WP_003101226.1 hypothetical protein -
MBA02_RS05240 (MBA02_005240) 1145278..1145778 + 501 WP_003112629.1 LEA type 2 family protein -
MBA02_RS05245 (MBA02_005245) 1145851..1146192 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
MBA02_RS05250 (MBA02_005250) 1146274..1147701 - 1428 WP_003083784.1 GABA permease -
MBA02_RS05255 (MBA02_005255) 1147870..1149363 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T252447 WP_003083773.1 NZ_CP101656:c1144157-1143876 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT252447 WP_003112628.1 NZ_CP101656:c1144381-1144154 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References