Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 3154050..3154618 Replicon chromosome
Accession NZ_CP101651
Organism Streptomyces sp. CRCS-T-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NNW99_RS13890 Protein ID WP_215119363.1
Coordinates 3154337..3154618 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NNW99_RS13885 Protein ID WP_251057782.1
Coordinates 3154050..3154331 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNW99_RS13860 (NNW99_13865) 3149343..3150116 + 774 WP_215119357.1 SDR family oxidoreductase -
NNW99_RS13865 (NNW99_13870) 3150236..3150943 + 708 WP_215119358.1 ester cyclase -
NNW99_RS13870 (NNW99_13875) 3151764..3152057 - 294 WP_215119360.1 hypothetical protein -
NNW99_RS13875 (NNW99_13880) 3152393..3153283 + 891 WP_215119361.1 hypothetical protein -
NNW99_RS13880 (NNW99_13885) 3153367..3154002 + 636 WP_251057781.1 hypothetical protein -
NNW99_RS13885 (NNW99_13890) 3154050..3154331 + 282 WP_251057782.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NNW99_RS13890 (NNW99_13895) 3154337..3154618 + 282 WP_215119363.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NNW99_RS13895 (NNW99_13900) 3154775..3155278 + 504 Protein_2761 DUF2791 family P-loop domain-containing protein -
NNW99_RS13900 (NNW99_13905) 3155292..3156335 - 1044 WP_251057783.1 hypothetical protein -
NNW99_RS13905 (NNW99_13910) 3156476..3158101 - 1626 WP_215119365.1 chaperonin GroEL -
NNW99_RS13910 (NNW99_13915) 3158223..3158531 - 309 WP_003974211.1 co-chaperone GroES -
NNW99_RS13915 (NNW99_13920) 3158877..3159608 - 732 WP_251057784.1 polysaccharide deacetylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10885.63 Da        Isoelectric Point: 10.8148

>T252446 WP_215119363.1 NZ_CP101651:3154337-3154618 [Streptomyces sp. CRCS-T-1]
MGYVTRFTPHAQRDMLKIPRPDALRILYRLTELQKAMDAGETAAFDVKALRGHNARWRLRVGDYRVVYTVEDGRVVVWVL
TVGNRREVYRQVP

Download         Length: 282 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10603.77 Da        Isoelectric Point: 4.3741

>AT252446 WP_251057782.1 NZ_CP101651:3154050-3154331 [Streptomyces sp. CRCS-T-1]
MSEPVVESMAEVRSHLADVIDRARRDKTPTIITRRGKREAVVIDIEEYQRLRQLAEDAEEAWLNRLADEAESEGTDGSVS
LEEMAALLRDQQH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References