Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4646767..4647548 Replicon chromosome
Accession NZ_CP101648
Organism Salmonella enterica subsp. enterica serovar Kentucky strain BCID6

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag NOQ95_RS22535 Protein ID WP_000625911.1
Coordinates 4646767..4647258 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag NOQ95_RS22540 Protein ID WP_001271379.1
Coordinates 4647255..4647548 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ95_RS22510 (4641903) 4641903..4644341 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
NOQ95_RS22515 (4644351) 4644351..4644890 - 540 WP_000721295.1 type 1 fimbrial protein -
NOQ95_RS22520 (4644925) 4644925..4645209 - 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
NOQ95_RS22525 (4645802) 4645802..4646029 + 228 WP_001112992.1 hypothetical protein -
NOQ95_RS22530 (4646304) 4646304..4646552 - 249 Protein_4382 IS481 family transposase -
NOQ95_RS22535 (4646767) 4646767..4647258 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
NOQ95_RS22540 (4647255) 4647255..4647548 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
NOQ95_RS22545 (4647866) 4647866..4648088 + 223 Protein_4385 hypothetical protein -
NOQ95_RS22550 (4648354) 4648354..4649229 + 876 WP_023205266.1 AraC family transcriptional regulator -
NOQ95_RS22555 (4649226) 4649226..4649513 + 288 WP_072103482.1 transcriptional regulator RtsB -
NOQ95_RS22560 (4649506) 4649506..4649688 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
NOQ95_RS22565 (4649708) 4649708..4649807 + 100 Protein_4389 hypothetical protein -
NOQ95_RS22570 (4649855) 4649855..4650049 + 195 WP_223163373.1 hypothetical protein -
NOQ95_RS22575 (4650345) 4650345..4651250 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4633745..4649688 15943


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T252444 WP_000625911.1 NZ_CP101648:c4647258-4646767 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT252444 WP_001271379.1 NZ_CP101648:c4647548-4647255 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References