Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4508584..4509227 Replicon chromosome
Accession NZ_CP101648
Organism Salmonella enterica subsp. enterica serovar Kentucky strain BCID6

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag NOQ95_RS21805 Protein ID WP_000048134.1
Coordinates 4508811..4509227 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag NOQ95_RS21800 Protein ID WP_001261294.1
Coordinates 4508584..4508814 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ95_RS21790 (4505597) 4505597..4507735 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
NOQ95_RS21795 (4507952) 4507952..4508416 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NOQ95_RS21800 (4508584) 4508584..4508814 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NOQ95_RS21805 (4508811) 4508811..4509227 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
NOQ95_RS21810 (4509288) 4509288..4511201 - 1914 WP_001212148.1 BglG family transcription antiterminator -
NOQ95_RS21815 (4511218) 4511218..4511958 - 741 WP_000779255.1 KDGP aldolase family protein -
NOQ95_RS21820 (4511955) 4511955..4513073 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NOQ95_RS21825 (4513057) 4513057..4514190 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T252443 WP_000048134.1 NZ_CP101648:4508811-4509227 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT252443 WP_001261294.1 NZ_CP101648:4508584-4508814 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References