Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3775465..3776085 Replicon chromosome
Accession NZ_CP101648
Organism Salmonella enterica subsp. enterica serovar Kentucky strain BCID6

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NOQ95_RS18445 Protein ID WP_001280991.1
Coordinates 3775867..3776085 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NOQ95_RS18440 Protein ID WP_000344807.1
Coordinates 3775465..3775839 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ95_RS18430 (3770604) 3770604..3771797 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NOQ95_RS18435 (3771820) 3771820..3774969 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NOQ95_RS18440 (3775465) 3775465..3775839 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NOQ95_RS18445 (3775867) 3775867..3776085 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NOQ95_RS18450 (3776264) 3776264..3776815 + 552 WP_001278793.1 maltose O-acetyltransferase -
NOQ95_RS18455 (3776933) 3776933..3777403 + 471 WP_000136183.1 YlaC family protein -
NOQ95_RS18460 (3777459) 3777459..3777599 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NOQ95_RS18465 (3777605) 3777605..3777865 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NOQ95_RS18470 (3778090) 3778090..3779640 + 1551 WP_000213145.1 EAL domain-containing protein -
NOQ95_RS18480 (3779871) 3779871..3780260 + 390 WP_023224410.1 MGMT family protein -
NOQ95_RS18485 (3780293) 3780293..3780862 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T252440 WP_001280991.1 NZ_CP101648:3775867-3776085 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT252440 WP_000344807.1 NZ_CP101648:3775465-3775839 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References