Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 587443..588203 | Replicon | chromosome |
| Accession | NZ_CP101648 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain BCID6 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A5H3Y7E3 |
| Locus tag | NOQ95_RS02815 | Protein ID | WP_023225088.1 |
| Coordinates | 587718..588203 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A3Z2K6C6 |
| Locus tag | NOQ95_RS02810 | Protein ID | WP_072106018.1 |
| Coordinates | 587443..587730 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NOQ95_RS02795 (583871) | 583871..584299 | + | 429 | Protein_529 | IS3 family transposase | - |
| NOQ95_RS02800 (584495) | 584495..585265 | - | 771 | WP_000456879.1 | DUF3800 domain-containing protein | - |
| NOQ95_RS02805 (586292) | 586292..587320 | + | 1029 | WP_023196719.1 | HNH endonuclease signature motif containing protein | - |
| NOQ95_RS02810 (587443) | 587443..587730 | + | 288 | WP_072106018.1 | DUF1778 domain-containing protein | Antitoxin |
| NOQ95_RS02815 (587718) | 587718..588203 | + | 486 | WP_023225088.1 | GNAT family N-acetyltransferase | Toxin |
| NOQ95_RS02820 (588573) | 588573..589112 | - | 540 | WP_000047141.1 | copper-binding periplasmic metallochaperone CueP | - |
| NOQ95_RS02825 (589285) | 589285..589497 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| NOQ95_RS02830 (589785) | 589785..590075 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| NOQ95_RS02835 (590514) | 590514..591224 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| NOQ95_RS02840 (591274) | 591274..592248 | - | 975 | WP_023225087.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| NOQ95_RS02845 (592467) | 592467..593129 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17756.43 Da Isoelectric Point: 9.0965
>T252431 WP_023225088.1 NZ_CP101648:587718-588203 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10982.66 Da Isoelectric Point: 4.6811
>AT252431 WP_072106018.1 NZ_CP101648:587443-587730 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H3Y7E3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Z2K6C6 |