Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4646752..4647533 Replicon chromosome
Accession NZ_CP101647
Organism Salmonella enterica subsp. enterica serovar Kentucky strain KCID6

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag NOQ94_RS22540 Protein ID WP_000625911.1
Coordinates 4646752..4647243 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag NOQ94_RS22545 Protein ID WP_001271379.1
Coordinates 4647240..4647533 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ94_RS22515 (4641888) 4641888..4644326 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
NOQ94_RS22520 (4644336) 4644336..4644875 - 540 WP_000721295.1 type 1 fimbrial protein -
NOQ94_RS22525 (4644910) 4644910..4645194 - 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
NOQ94_RS22530 (4645787) 4645787..4646014 + 228 WP_001112992.1 hypothetical protein -
NOQ94_RS22535 (4646289) 4646289..4646537 - 249 Protein_4383 IS481 family transposase -
NOQ94_RS22540 (4646752) 4646752..4647243 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
NOQ94_RS22545 (4647240) 4647240..4647533 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
NOQ94_RS22550 (4647851) 4647851..4648072 + 222 WP_052939504.1 hypothetical protein -
NOQ94_RS22555 (4648338) 4648338..4649213 + 876 WP_023205266.1 AraC family transcriptional regulator -
NOQ94_RS22560 (4649210) 4649210..4649497 + 288 WP_072103482.1 transcriptional regulator RtsB -
NOQ94_RS22565 (4649490) 4649490..4649672 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
NOQ94_RS22570 (4649692) 4649692..4649791 + 100 Protein_4390 hypothetical protein -
NOQ94_RS22575 (4649839) 4649839..4650033 + 195 WP_223163373.1 hypothetical protein -
NOQ94_RS22580 (4650328) 4650328..4651233 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4633729..4649672 15943


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T252428 WP_000625911.1 NZ_CP101647:c4647243-4646752 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT252428 WP_001271379.1 NZ_CP101647:c4647533-4647240 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References