252427

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4508566..4509209 Replicon chromosome
Accession NZ_CP101647
Organism Salmonella enterica subsp. enterica serovar Kentucky strain KCID6

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag NOQ94_RS21815 Protein ID WP_000048134.1
Coordinates 4508793..4509209 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag NOQ94_RS21810 Protein ID WP_001261294.1
Coordinates 4508566..4508796 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ94_RS21800 (4505579) 4505579..4507717 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
NOQ94_RS21805 (4507934) 4507934..4508398 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NOQ94_RS21810 (4508566) 4508566..4508796 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NOQ94_RS21815 (4508793) 4508793..4509209 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
NOQ94_RS21820 (4509270) 4509270..4511183 - 1914 WP_001212148.1 BglG family transcription antiterminator -
NOQ94_RS21825 (4511200) 4511200..4511940 - 741 WP_000779255.1 KDGP aldolase family protein -
NOQ94_RS21830 (4511937) 4511937..4513055 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NOQ94_RS21835 (4513039) 4513039..4514172 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T252427 WP_000048134.1 NZ_CP101647:4508793-4509209 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT252427 WP_001261294.1 NZ_CP101647:4508566-4508796 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References